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Maike Krenz Selected Research

LEOPARD Syndrome (Syndrome, LEOPARD)

5/2015Elevated Ca2+ transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines.
1/2015The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration.
6/2013New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling.

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Maike Krenz Research Topics

Disease

5Hypertrophy
04/2016 - 12/2004
4Cardiomegaly (Heart Hypertrophy)
01/2022 - 06/2013
4Heart Failure
11/2017 - 01/2013
4Ischemia
12/2016 - 05/2002
3Heart Diseases (Heart Disease)
01/2022 - 12/2004
3Congenital Heart Defects (Congenital Heart Defect)
01/2022 - 01/2012
3LEOPARD Syndrome (Syndrome, LEOPARD)
05/2015 - 06/2013
3Infarction (Infarctions)
10/2007 - 05/2002
2Fibrosis (Cirrhosis)
01/2016 - 01/2013
2Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
05/2015 - 06/2013
2Noonan Syndrome (Female Pseudo-Turner Syndrome)
01/2015 - 10/2005
2Myocardial Infarction
01/2012 - 05/2002
1Hypoxia (Hypoxemia)
01/2022
1Hypertension (High Blood Pressure)
05/2016
1Mitochondrial Diseases (Mitochondrial Disease)
04/2016
1Pulmonary Valve Stenosis (Pulmonary Stenosis)
05/2015
1Necrosis
04/2014
1Reperfusion Injury
04/2014
1Stroke (Strokes)
01/2012
1Rupture
01/2012
1Ischemic Stroke
01/2012
1Binge Drinking
01/2012
1Cardiomyopathies (Cardiomyopathy)
05/2010
1Myocardial Ischemia (Ischemic Heart Diseases)
04/2004

Drug/Important Bio-Agent (IBA)

6Protein Tyrosine PhosphatasesIBA
01/2022 - 10/2005
4Ethanol (Ethyl Alcohol)IBA
01/2012 - 05/2002
3Protein Isoforms (Isoforms)IBA
11/2017 - 12/2004
3CalciumIBA
12/2016 - 01/2012
2Adenosine Triphosphatases (ATPase)IBA
12/2016 - 01/2012
2CollagenIBA
04/2016 - 01/2013
2Isoproterenol (Isoprenaline)FDA LinkGeneric
11/2013 - 12/2004
1Interleukin-18 (Interleukin 18)IBA
05/2016
1setanaxibIBA
05/2016
1Tadalafil (Cialis)FDA Link
04/2016
1Guanosine Monophosphate (5' Guanylic Acid)IBA
04/2016
1Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
04/2016
1saxagliptinFDA Link
04/2016
1Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
04/2016
1Metformin (Glucophage)FDA LinkGeneric
01/2016
1AldosteroneIBA
01/2016
1CytokinesIBA
01/2016
1Cyclosporine (Ciclosporin)FDA LinkGeneric
06/2014
1ActininIBA
04/2014
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
04/2014
1MyoglobinIBA
04/2014
1Phosphopyruvate Hydratase (Enolase)IBA
04/2014
1Proteins (Proteins, Gene)FDA Link
04/2014
1Biomarkers (Surrogate Marker)IBA
04/2014
1StaurosporineIBA
04/2014
1HMGB1 Protein (HMG1)IBA
04/2014
114-3-3 Proteins (14-3-3 Protein)IBA
04/2014
1HexokinaseIBA
11/2013
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2013
1Fatty Acids (Saturated Fatty Acids)IBA
11/2013
1Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA
11/2013
1Glucose (Dextrose)FDA LinkGeneric
11/2013
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
11/2013
1Dehydroepiandrosterone (DHEA)IBA
11/2013
1TOR Serine-Threonine KinasesIBA
06/2013
1Focal Adhesion Protein-Tyrosine KinasesIBA
06/2013
1Messenger RNA (mRNA)IBA
01/2013
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
01/2013
1Oxygen (Dioxygen)IBA
01/2013
1Metalloproteases (Metalloproteinases)IBA
01/2013
1RNA IsoformsIBA
01/2013
1Lactic Acid (Lactate)FDA LinkGeneric
01/2012
1Adenosine Triphosphate (ATP)IBA
01/2012
1Cardiac MyosinsIBA
05/2010
1MM Form Creatine KinaseIBA
04/2010
1Hemagglutinins (Hemagglutinin)IBA
04/2010
1Mitogen-Activated Protein Kinase 3IBA
10/2005
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
10/2005
1Mitogen-Activated Protein KinasesIBA
10/2005
1triphenyltetrazoliumIBA
09/2002
1mitochondrial K(ATP) channelIBA
05/2002
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
05/2002
1Diazoxide (Hyperstat)FDA Link
05/2002

Therapy/Procedure

2Therapeutics
11/2017 - 06/2013
1Ligation
10/2007